The Omega Syndrome is an old school computer role playing game similar to Fallout, with a story inspired by the X-Files television series and the Roswell Incident.

Character creation starts with adjusting strength, perception, endurance, intelligence, agility, and luck. You can Tag four skills: guns, laser weapons, melee, throwing weapons. Not only can you target the bad guys, you can be poisoned, radiated, and receive damage to left and right arms and legs. Your armor class improves when you buy leather jackets or opt for Kevlar armor. The higher you level or improve your specific skills, the higher your critical chance to hit. You can also equip yourself with gas masks, drink health or poison concoctions to become resistant/repair health, poison, radiation, gas inhalation, gas contact and electrified damage. Melee weapons include a bat, crowbar and of course fists. Projectile weapons include a 9mm (WP, FMJ) handgun, 7.62 rifle, crossbow, and laser pistol.

Turn-based combat is similar to Jagged Alliance where each player takes their turn attacking. All members of the party have the ability for targeting eyes head, torso, either right or left arm/legs, and groan. A hit to the eyes can cause enemy blindness, henceforth, the enemy fire wildly, unable to target you again. The 800 by 600 graphics fall between Jagged Alliance 1 and Fallout. There is only a single interface for both exploring and combat, yet it contains all necessary information. Trading in stores or with people you meet is also possible and necessary to complete your objectives. Money and ammo are scarce so use melee weapons to begin with; you can always heal your team, merely by resting between battles.